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A MAJOR risk factor for diabetes and heart disease, Metabolic Syndrome, also known as the deadly quartet is a condition involving high triglycerides, low HDL-"good" cholesterol level, high blood pressure, and high fasting blood sugar. It also is linked to overweight and now, gut microbes – Bacteria that are indigenous to the intestine– and which perform many key functions in health: when gut microbiology becomes dysregulated it can lead to chronic inflammatory diseases; as well, An altered gut microbiota promotes inflammation that leads to Metabolic Syndrome.
Employing an animal research model, Andrew Gewirtz, from Georgia State University (Georgia, USA), and colleagues observed that promoting healthy gut microbiota in mice can prevent Metabolic Syndrome. The study authors observe that: “Expression of [Toll-like receptor 5] on [intestinal epithelial cells] regulates the composition and localization of the intestinal microbiota, preventing diseases associated with intestinal inflammation.”
This is unbelievably important news for many people concerned with risk of this disorder or who are already suffering from this disorder. Please contact me for help with testing and correcting this underlying scenario. This is an exciting discovery and should lead to much better health prognosis for this population.
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This study was recently published in the Journal of Gastroenterology.
Chassaing B, Ley RE, Gewirtz AT. “Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice.” Gastroenterology. 2014 Dec;147(6):1363-1377.e17.
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