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Kavinace by NeuroScience - Free Shipping   This product has been discontinued by the manufacturer, please see Kavinace OS by Neuroscience or Kavinace OS Emulsion by Neuroscience for the new version.   Holistic Doctor Recommended   Kavinace by Neuroscience combines two powerful ingredients that have shown to be effective at addressing symptoms of stress, anxiousness, irritability, hyperactivity, and sleep problems. Kavinace anxiety support supplement contains the GABA derivative, Phenibut which crosses the blood brain barrier more easily than GABA.   Kavinace 120 Capsules by NeuroScience contains:   Most calming product* Provides GABA support to help manage stress and anxiousness and promote healthy sleep.* (120 Capsules per bottle)    Suggested Use:   Take 1-2 capsules one to two times daily or as directed by your healthcare provider. Suggested at bedtime.   GABA is the primary inhibitory neurotransmitter in the brain, meaning its central role is to balance excitability of neurons (1). Because of its function, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5). Ingredients such as taurine and vitamin B6 are important for glutamate-GABA balance.* High glutamate can damage neurons, alter cellular homeostasis, and cause mitochondrial dysfunction, which can ultimately lead to cell death (6). Taurine demonstrates GABA-A agonist activity and protects neurons and mitochondria against glutamate-induced damage (6,7).* Active form of vitamin B6 is important for the synthesis of GABA as it is a required cofactor for glutamate decarboxylase, the enzyme responsible for converting glutamate to GABA (8-10).* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Kavinace Ultra PM by Neuroscience - Free Shipping   This product has been discontinued by the manufacturer, please see Kavinace OS by Neuroscience or Kavinace OS Emulsion by Neuroscience for the new version.   Holistic Doctor Recommended Kavinace Ultra PM by Neuroscience 30 capsules   Blend of ingredients shown to improve onset and quality of sleep* Kavinace Ultra PM provides the strongest sleep support among Kavinace products**   Supplement Facts Serving Size 1 Capsule Servings Per Container 30   Amount Per Serving *%DV Melatonin 3 mg † Proprietary Blend 4-amino-3-phenylbutyric acid, 5-hydroxytryptophan (from  Griffonia simplicifolia seed extract) 650 mg † Other Ingredients: Vegetable capsule (HPMC and water), Microcrystalline Cellulose, and Magnesium  Stearate (vegetable source). Does not contain gluten, corn, soy, salt, sucrose/starch,  yeast, artificial flavors, or artificial colors.   4-amino-3-phenylbutyric acid crosses the blood brain barrier and binds GABA-B receptors*1 GABA is associated with mood and anxiousness2 5-HTP is a precursor to serotonin*3 Serotonin is associated with mood and sleep4 Melatonin is important for the regulation of the sleep-wake cycle*5     Suggested Use:   Take 1 capsule at bedtime as needed or as directed by your healthcare provider.  Use caution when combined with medications that have sedative properties. Use under the supervision of a licensed healthcare practitioner. If you are pregnant or nursing, consult your healthcare practitioner before use. Kavinace Ultra PM is uniquely designed to promote sleep by promoting healthy levels of the primary neurotransmitters and hormones involved in sleep. It is frequently recommended for patients with elevated levels of glutamate and PEA, decreased levels of serotonin and melatonin, and may be beneficial in some individuals with elevated epinephrine and norepinephrine.   GABA is the primary inhibitory neurotransmitter in the brain, which means it plays a central role in balancing the excitability of neurons (1). Because of this reason, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5). The effects of Kavinace Ultra PM have been studied in a randomized, placebo-controlled study. One capsule of Kavinace Ultra PM taken at bedtime for 5 days significantly improved quality of sleep as measured by the Pittsburgh Sleep Quality Index (6).* Participants taking Kavinace Ultra PM reported decreased time to fall asleep, increased duration of sleep, and decreased sleep disturbances (6).* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. **Relative amounts of ingredients as compared to other Kavinace products      

Kavinace OS Emulsion by Neuroscience   Holistic Doctor Recommended Chocolate Coconut Flavored Emulsion 8 fl oz (15 servings)   Kavinace OS Emulsion by Neuroscience is a Comprehensive blend of antioxidants shown to improve the onset, duration, and efficiency of sleep while addressing oxidative stress*   Biomarkers Neurotransmitter: Glutamate Hormone: Melatonin Ingredients Amino Acid: L-theanine Vitamin/Mineral: Magnesium Vitamin E Selenium Zinc Other: Astaxanthin Melatonin Resveratrol Suggested Use Take 1 tablespoon (15 mL) at bedtime or as directed by your healthcare provider. Do not exceed suggested use. If you are pregnant or nursing, consult your healthcare provider before use  

Kavinace OS by Neuroscience - Free Shipping   60 capsules per bottle   Holistic Doctor Recommended Kavinace OS is a Comprehensive blend of antioxidants shown to improve the onset, duration, and efficiency of sleep while addressing oxidative stress*   Biomarkers Neurotransmitter: Glutamate Hormone: Melatonin Ingredients Amino Acid: L-theanine Vitamin/Mineral: Magnesium Selenium Zinc Other: Astaxanthin Melatonin Resveratrol Suggested Use: Take 2 capsules at bedtime or as directed by your healthcare provider. Do not exceed suggested use. If you are pregnant or nursing, consult your healthcare provider before use.